Sildenafil vs Vardenafil

PDE5 inhibitor

PDE5 inhibitor

The original ED pill, taken about an hour before sex, with a shorter and more predictable window than tadalafil.

An ED pill similar in timing to sildenafil, sometimes chosen when other PDE5 inhibitors cause bothersome side effects.

Erectile dysfunction

Erectile dysfunction

• Erectile dysfunction
• Pulmonary arterial hypertension (as Revatio)

• Erectile dysfunction

• ED: 50 mg about 1 hour before activity (range 25–100 mg), no more than once daily
• Onset about 30–60 minutes; effect lasts roughly 4–6 hours
• A heavy or high-fat meal can delay how fast it works

• ED: 10 mg about 1 hour before activity (range 5–20 mg), no more than once daily
• Orally disintegrating tablet (Staxyn): 10 mg, not interchangeable milligram-for-milligram with film-coated tablets
• Onset about 30–60 minutes; effect lasts roughly 4–6 hours

• Headache
• Flushing
• Indigestion
• Nasal congestion
• Dizziness
• Bluish or blurred vision

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing

• Headache
• Flushing
• Nasal congestion
• Indigestion
• Dizziness

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing
• QT-interval prolongation

• Adult men with erectile dysfunction
• Men who prefer a shorter, more predictable duration and often the lowest cash price per dose

• Adult men with erectile dysfunction
• Men who did not tolerate or respond to another PDE5 inhibitor

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Known hypersensitivity to sildenafil

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Use with Class IA (e.g. quinidine) or Class III (e.g. amiodarone) antiarrhythmics
• Congenital QT prolongation
• Known hypersensitivity to vardenafil

• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status
• Effectiveness may be reduced when taken with a high-fat meal

• Can prolong the QT interval; use caution in patients at risk
• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status