Tadalafil vs Sildenafil

PDE5 inhibitor

PDE5 inhibitor

A long-acting ED pill that can work for up to 36 hours from a single dose, so timing is flexible.

The original ED pill, taken about an hour before sex, with a shorter and more predictable window than tadalafil.

Erectile dysfunction / BPH

Erectile dysfunction

• Erectile dysfunction
• Benign prostatic hyperplasia (BPH)
• Erectile dysfunction with BPH
• Pulmonary arterial hypertension (as Adcirca)

• Erectile dysfunction
• Pulmonary arterial hypertension (as Revatio)

• ED as-needed: 10 mg before activity (range 5–20 mg)
• ED once-daily: 2.5–5 mg taken at the same time each day
• BPH: 5 mg once daily
• Onset about 30 minutes to 2 hours; effect lasts up to 36 hours

• ED: 50 mg about 1 hour before activity (range 25–100 mg), no more than once daily
• Onset about 30–60 minutes; effect lasts roughly 4–6 hours
• A heavy or high-fat meal can delay how fast it works

• Headache
• Flushing
• Back pain
• Muscle aches
• Nasal congestion
• Indigestion

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing

• Headache
• Flushing
• Indigestion
• Nasal congestion
• Dizziness
• Bluish or blurred vision

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing

• Adult men with erectile dysfunction
• Men with signs and symptoms of BPH
• Men who prefer dosing flexibility over planning around a pill

• Adult men with erectile dysfunction
• Men who prefer a shorter, more predictable duration and often the lowest cash price per dose

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Known hypersensitivity to tadalafil

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Known hypersensitivity to sildenafil

• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status
• Use caution with alcohol, which can add to blood-pressure lowering

• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status
• Effectiveness may be reduced when taken with a high-fat meal