Tadalafil vs Vardenafil

PDE5 inhibitor

PDE5 inhibitor

A long-acting ED pill that can work for up to 36 hours from a single dose, so timing is flexible.

An ED pill similar in timing to sildenafil, sometimes chosen when other PDE5 inhibitors cause bothersome side effects.

Erectile dysfunction / BPH

Erectile dysfunction

• Erectile dysfunction
• Benign prostatic hyperplasia (BPH)
• Erectile dysfunction with BPH
• Pulmonary arterial hypertension (as Adcirca)

• Erectile dysfunction

• ED as-needed: 10 mg before activity (range 5–20 mg)
• ED once-daily: 2.5–5 mg taken at the same time each day
• BPH: 5 mg once daily
• Onset about 30 minutes to 2 hours; effect lasts up to 36 hours

• ED: 10 mg about 1 hour before activity (range 5–20 mg), no more than once daily
• Orally disintegrating tablet (Staxyn): 10 mg, not interchangeable milligram-for-milligram with film-coated tablets
• Onset about 30–60 minutes; effect lasts roughly 4–6 hours

• Headache
• Flushing
• Back pain
• Muscle aches
• Nasal congestion
• Indigestion

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing

• Headache
• Flushing
• Nasal congestion
• Indigestion
• Dizziness

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing
• QT-interval prolongation

• Adult men with erectile dysfunction
• Men with signs and symptoms of BPH
• Men who prefer dosing flexibility over planning around a pill

• Adult men with erectile dysfunction
• Men who did not tolerate or respond to another PDE5 inhibitor

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Known hypersensitivity to tadalafil

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Use with Class IA (e.g. quinidine) or Class III (e.g. amiodarone) antiarrhythmics
• Congenital QT prolongation
• Known hypersensitivity to vardenafil

• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status
• Use caution with alcohol, which can add to blood-pressure lowering

• Can prolong the QT interval; use caution in patients at risk
• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status