Vardenafil vs Avanafil

PDE5 inhibitor

PDE5 inhibitor

An ED pill similar in timing to sildenafil, sometimes chosen when other PDE5 inhibitors cause bothersome side effects.

The newest ED pill, designed for fast onset — some men can take it as little as 15 minutes before sex.

Erectile dysfunction

Erectile dysfunction

• Erectile dysfunction

• Erectile dysfunction

• ED: 10 mg about 1 hour before activity (range 5–20 mg), no more than once daily
• Orally disintegrating tablet (Staxyn): 10 mg, not interchangeable milligram-for-milligram with film-coated tablets
• Onset about 30–60 minutes; effect lasts roughly 4–6 hours

• ED: 100 mg about 15–30 minutes before activity (range 50–200 mg), no more than once daily
• The 100 mg and 200 mg doses may be taken as early as 15 minutes before activity
• Effect lasts roughly 4–6 hours

• Headache
• Flushing
• Nasal congestion
• Indigestion
• Dizziness

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing
• QT-interval prolongation

• Headache
• Flushing
• Nasal congestion
• Back pain

• Priapism (erection lasting more than 4 hours)
• Sudden loss of vision (NAION)
• Sudden loss or decrease in hearing

• Adult men with erectile dysfunction
• Men who did not tolerate or respond to another PDE5 inhibitor

• Adult men with erectile dysfunction
• Men who want the fastest onset among PDE5 inhibitors

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Use with Class IA (e.g. quinidine) or Class III (e.g. amiodarone) antiarrhythmics
• Congenital QT prolongation
• Known hypersensitivity to vardenafil

• Use with nitrates in any form
• Use with the guanylate cyclase stimulator riociguat
• Known hypersensitivity to avanafil

• Can prolong the QT interval; use caution in patients at risk
• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status

• Additive low blood pressure when combined with alpha-blockers or antihypertensives
• Blood levels increase with strong CYP3A4 inhibitors such as ketoconazole or ritonavir
• Not recommended in men for whom sexual activity is inadvisable due to cardiovascular status
• Use caution with alcohol, which can add to blood-pressure lowering